Endocrine Abstracts

A 19 year old male was referred urgently due to a significantly raised Prolactin. He had seen his GP due to a cough, who then noted the patient had not progressed through puberty and organized further testing. On examination he had a BMI of 47. His height was 178 cm with a target of 184.5 cm (range 176-193). He had bilateral gynaecomastia with micropenis and pre-pubertal testes. He had never shaved and his voice was high-pitched. He did not report anosmia. Visual fields were n...

A 33-year-old male with a background of idiopathic hypogonadotrophic hypogonadism was referred to the endocrine clinic to discuss fertility. He was originally diagnosed overseas when presented with delayed puberty in late teens. He had a normal pituitary MRI and since then he had been on testosterone replacement; other pituitary function was normal. He was not anosmic however no other information was available from diagnosis. When he attended the clinic the patient and his wif...

Background: CYP3A4 is the most prevalent cytochrome P450 (CYP) enzyme in the liver, and is used by the majority of medications for their metabolism and elimination from the body. The inhibition of CYP3A4 can result in the accumulation of drug concentrations increasing the risk for possible toxicity. We report a case of iatrogenic Cushings’s syndrome secondary to impaired CYP3A4 metabolism of triamcinolone by coadministration of darunavir/cobicistat, with resultant seconda...

A 69 year old male was referred with a 60 year history of recurrent hypoglycaemia. Over the previous 12 months he had several episodes of severe hypoglycaemia, which necessitated emergency treatment from paramedics. He had been diagnosed with a hypoglycaemic disorder at the age of 9 years, but no underlying cause had been identified. He had no other previous history of note, though he was macrosomic at birth with a birth weight of approximately 5.9 kg. His mother was diagnosed...

Background: Given the technically challenging nature of adrenal venous sampling (AVS) there is a drive to centralise services to improve successful outcomes. This has potential implications for patients living in remote and rural areas.Methods: We retrospectively reviewed the case notes of 15 patients who underwent AVS in our hospital, for investigation of primary hyperaldosteronism between 2002 and 2015. We assessed the success rate of cannulation of th...